Mei Hong
    Professor of Chemistry
     Massachusetts Institute of Technology
     170 Albany Street, NW14-3212
     Cambridge, MA, 02139
     Tel: 617-253-5521
1992 - 1996 Ph.D. Chemistry, University of California Berkeley
1990 - 1992 B. A. Chemistry, summa cum laude, Mount Holyoke College
2014 -             Professor of Chemistry, Massachusetts Institute of Technology
2007 - 2010    John D. Corbett Professor, Iowa State University (ISU)
2004 - 2014    Professor of Chemistry, ISU
2002 - 2004    Associate Professor, Department of Chemistry, ISU
1999 - 2002    Assistant Professor, Department of Chemistry, ISU
1997 - 1999    Research Assistant Professor, University of Massachusetts Amherst
1996 - 1997    Postdoctoral Fellow, Department of Chemistry, MIT
Awards and Honors
      2014    Günther Laukien Prize, Experimental NMR Conference
       2013    Award for Outstanding Career Achievement in Research, Iowa State University (ISU)
       2012    Protein Society Irving Sigal Young Investigator Award
       2010    Founders Medal, International Council on Magnetic Resonance in Biological Systems
       2010    Fellow of the American Association for the Advancement of Science
       2007    The first John D. Corbett Professorship
       2007    Mid-Career Research Award, ISU
       2006    Agnes Fay Morgan Research Award, Iota Sigma Pi
       2004    Mary Lyon Award, Mount Holyoke College
       2003    Early Achievement in Research/Artistic Creativity Award, ISU
       2003    Pure Chemistry Award, American Chemical Society
       2002    Alfred P. Sloan Research Fellow, Sloan Foundation
       2001    CAREER Award, National Science Foundation
       2000    Research Innovation Award, Research Corporation
       1999    Beckman Young Investigator Award, Beckman Foundation
       1998    POWRE Award, National Science Foundation
       1997    National Institute of Health Postdoctoral Fellowship
       1992    American Chemical Society Undergraduate Award, Mount Holyoke College
Research Interests
        My research focuses on the development and applications of solid-state NMR spectroscopy to elucidate the structure and dynamics of membrane proteins and other biological molecules. We are particularly interested in the mechanistic structural biology of ion channels and curvature-inducing membrane proteins. Our research has elucidated 1) the drug binding site and inhibition mechanism of the influenza M2 protein and the proton conduction mechanism of this proton channel, 2) the membrane-bound oligomeric structure of b-hairpin antimicrobial peptides and the mechanism with which these arginine-rich cationic peptides insert into lipid membranes against the free energy barrier, and 3) the conformational and dynamical changes of a channel-forming colicin during its insertion into the lipid membrane. We also investigate the structure of biomaterials such as plant cell walls.
            To enable these biological studies, we develop a wide variety of solid-state NMR techniques, such as 1) multidimensional correlation techniques, computational methods and isotopic labeling strategies for resonance assignment of proteins, 2) anisotropic-isotropic correlation techniques to measure torsion angles, molecular motion, and chemical shift tensors, 3) long-range distance techniques, and 4) intermolecular correlation techniques to determine membrane protein depth of insertion and hydration.
           By December 2015, 154 papers published, with a cumulative h-index of 47.